NAD+ nasal spray vs injection

Coenzyme NAD+ (nicotinamide adenine dinucleotide) is essential for a number of metabolic functions in the body. It is a component of every living cell and plays a role in cell signalling, DNA repair, and energy synthesis. As we age, NAD+ levels drop, which is thought to have a role in a number of age-related illnesses such cognitive decline, metabolic issues, and cardiovascular disease. In recent years, the usage of NAD+ supplements, such as NAD+ injection and nasal spray, has grown in favour as a means of increasing NAD+ levels and enhancing general health.

This article will examine the distinctions between NAD+ nasal spray and injection, as well as their advantages, potential drawbacks, and efficacy in raising NAD+ levels in the body.                     

NAD+ nasal spray vs injection

NAD+ Nasal Spray:

A supplement called NAD+ nasal spray is administered through the nasal passages. Typically, it is generated by combining NAD+ with a saline solution to produce a fine mist that is simple to breathe in. Bypassing the digestive system, which can occasionally break down supplements before they can be effectively absorbed by the body, is the premise behind utilising a nasal spray to provide NAD+.

Advantages of nasal spray NAD+ :-

Rapid Absorption:

The fast body absorption of NAD+ nasal spray is one of its key advantages. The NAD+ mist can quickly enter the bloodstream and be carried to the cells that require it since the nasal passages have a plentiful blood supply.

Non-Invasive and Convenient:

The ease of use and non-intrusiveness of NAD+ nasal spray are additional benefits. Nasal sprays can be simply delivered by the user without the help of a doctor, unlike injections, which call for a needle.

Possibility of Increased Cognitive Performance:

Some data points to the potential for cognitive benefits of NAD+ nasal spray. Daily nasal delivery of NAD+ improved cognitive function in a mouse model of Alzheimer’s disease, according to a study printed in the Journal of Alzheimer’s Disease. This is an area of ongoing exploration, albeit additional study is required to discover whether these advantages also apply to humans.

Disadvantage of using NAD+ nasal spray:-

Despite the fact that NAD+ nasal spray is generally regarded as safe, users should be aware of some possible negative effects, such as:

Irritated nose:

After taking NAD+ nasal spray, some individuals may suffer moderate nasal discomfort. This can cause a burning or stinging feeling, and people with sensitive nasal passages may experience it more frequently.


NAD+ nasal spray frequently causes headaches as a side effect, particularly in first-time users. These headaches are typically minor and disappear quickly on their own.

Irritation, Nausea and Vomiting:

NAD+ nasal spray may cause nausea or vomiting in certain users. Often, this is a brief side effect that goes away on its own. 

Injection of NAD+ :-

NAD+ is injected directly into the bloodstream during a NAD+ injection. This often involves the use of a needle and is performed by a medical expert. NAD+ can enter the bloodstream quickly thanks to the injection’s ability to avoid the digestive system.

Advantages of Injecting NAD+ :-

1. Quick Absorption:

One of the key advantages of using NAD+ injection is that it enables NAD+ to enter the bloodstream quickly. When employing NAD+ to treat acute illnesses like drug overdose or alcohol withdrawal, this can be especially crucial.

2. High Bioavailability:

Injections of NAD+ also have a high bioavailability, which means that a significant portion of the NAD+ is able to enter the cells and tissues that require it the most. This is so that the injection can avoid the digestive system, where NAD+ may occasionally be damaged before it is completely absorbed.

3. Potential Neuroprotective Effects:

The injection of NAD+ may have neuroprotective effects, according to some evidence. In a mouse model of ischemic stroke, NAD+ infusion was able to prevent neuronal damage, according to a study published in the journal Nature Communications. This is an area of ongoing exploration, albeit additional study is required to discover whether these advantages also apply to humans.

NAD+ Infusion Side Effects:-

Despite the fact that NAD+ injection is generally regarded as safe, users should be aware of a few possible negative effects, such as:

1. Aches or Pains at the Injection Site:

The injection site for NAD+ injection can occasionally experience pain or discomfort. Usually, this is a minor, transient adverse effect that disappears on its own.

2. Allergic Response:

An allergic reaction to NAD+ injection is quite uncommon. This could show up as hives, scratching, or breathing issues. After receiving an injection, anyone who suffers from these symptoms should visit a doctor right away.

3. Unsteadiness or faintness:

After receiving an injection of NAD+, some people may feel faint or dizzy. Usually, this is a brief side effect that disappears on its own.

Which is better, an injection or a nasal spray of NAD+?

In the end, the decision between NAD+ injection and nasal spray comes down to personal needs and preferences. Each technique has benefits and drawbacks of its own.

NAD+ nasal spray may be a better option for those :-

Who Prefer a non-invasive delivery method are utilising NAD+ for general health objectives. Need a supplement that is simple to use and convenient, but doesn’t need NAD+ to be absorbed quickly.

NAD+ injection, however, might be a preferable choice for those who:

  • Require NAD+ to be absorbed quickly.
  • Are treating acute illnesses with NAD+.
  • Need a dietary supplement with high bioavailability.
  • Possess no fear of using needles.

It is crucial to remember that NAD+ injection and nasal spray both have the capacity to raise the body’s NAD+ levels. Before using any NAD+ supplement, though, it’s vital to read the manufacturer’s instructions and speak with a doctor because the precise dosages and formulations of different products may vary.

Drawbacks of NAD+ nasal spray and injection

The usage of NAD+ nasal spray and injection has certain possible drawbacks in addition to the information that has already been discussed.


The price is one restriction. As compared to other supplements on the market, NAD+ pills might be quite pricey. NAD+ nasal spray and injection prices can change based on the exact product and dosage, so it’s crucial to factor in any potential costs before using these supplements.

Lack of long-term safety:

The absence of long-term safety and efficacy data is another drawback. While some early trials on NAD+ supplements have shown promise, additional study is required to confirm their long-term usefulness and safety. Furthermore, it’s crucial to remember that not all NAD+ supplements are made equal and that some may work better than others.

Risk factors:

Before beginning any new supplement regimen, it’s crucial to weigh the advantages and disadvantages of supplementing with NAD+. Despite being largely regarded as safe, NAD+ supplements can nonetheless have negative side effects and interact with other drugs. Before utilising any new supplement, it is crucial to speak with a healthcare professional to be sure it is secure and suitable for your particular requirements.

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NAD+ can be added to the body by two common methods: injection and nasal spray. The decision between the two ways ultimately comes down to the needs and preferences of the individual, even though each method has advantages and potential drawbacks of its own. While NAD+ injection may be a better choice for people who need rapid absorption of NAD+ or are using it to treat acute problems, NAD+ nasal spray may be a more practical and non-invasive option for general health purposes. Regardless of the approach, it’s critical to adhere to the manufacturer’s recommendations and seek medical advice before utilising any NAD+ supplements. Before beginning a new regimen, speak with a medical professional, and keep an eye out for any possible side effects or interaction with other medications. 


Is NAD+ healthy to take?

The chemical nicotinamide adenine dinucleotide, or NAD+, is crucial to numerous biological activities. Natural NAD+ levels decline with age, however nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) supplements have been proven to boost cellular NAD+ levels. A healthcare provider should always be consulted before beginning any new supplements, even though there is encouraging research on the potential health benefits of NAD+ supplementation. More research is necessary to fully understand its effects.

Can I take NAD+ everyday? 

Long-term NAD+ supplementation’s efficacy and safety are still being researched. The best course of action is to speak with a healthcare professional before beginning any new supplements, even if some research indicates that ingesting NAD+ precursors on a daily basis may raise NAD+ levels in cells. Depending on a person’s health conditions and whatever drugs or supplements they are currently taking, the right amount and frequency of NAD+ supplementation may differ.

What are the side effects of NAD+ Nasal spray?

There hasn’t been much research done on the potential adverse effects of NAD+ nasal spray because it’s a relatively new medication. But, a few people have mentioned mild side effects like headaches, nausea, and dizziness. Compared to other types of NAD+ supplementation, NAD+ nasal spray is a direct administration approach, which may raise the risk of side effects. When starting any new supplements, it’s crucial to follow the directions on the bottle and see your doctor first, especially if you have any pre-existing medical conditions or are taking drugs that might interfere with NAD+.